Femara 2,5 mg

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Femara 2,5 mg

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Categories: Drugs, Health, Pharmacy

Explore how Femara (letrozole) effectively treats hormone receptor-positive breast cancer in postmenopausal women by reducing estrogen levels. Learn about its benefits, side effects, and role in treatment plans.

Description

Femara (letrozole) is an oral medication primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. As an aromatase inhibitor, Femara works by reducing estrogen levels in the body, which can help slow or stop the growth of certain types of breast tumors that require estrogen to grow.

When the growth of a tumoral fabric depends on the presence of estrogen, elimination of the stimulating influences mediated by them is the precondition for suppression of growth of a tumor. At women in postmenopause estrogen is formed mainly at the participation of enzyme of aromatase, which transforms the androgens synthesized in adrenal glands (first of all, androstenedione and testosterone) into estrone and estradiol. Therefore it is possible to reach suppression of biosynthesis of estrogen in peripheral fabrics and in a tumoral fabric by means of specific inhibition of enzyme of aromatase.

Femara is appointed as a first-line preparation of the therapy of the widespread forms of a cancer of a mammary gland at women in postmenopause.
The preparation is used for the treatment of the widespread forms of a cancer of a mammary gland at women in postmenopause (natural or artificially caused), who have received the previous therapy by antiestrogen.

Collateral actions

The undesirable phenomena noted in clinical researches were basically poorly or moderately expressed. The undesirable phenomena of a significant degree of the expressiveness demanding the termination of treatment, have been registered only in rare cases. Many undesirable phenomena can be caused both by the basic disease, and natural pharmacological consequences of deficiency of estrogen (for example, inflow, thinning of hair).

Below are listed the undesirable phenomena registered in controllable clinical research of preparation Femara, which was appointed to 174 patients in a daily dose of 2.5 mg during the period 33 months. The connection of this undesirable phenomenon with the application of Femara has been regarded by researchers as possible.

  • From the CNS: headache, dizziness, general weakness.
  • From the digestive system: nausea, vomiting, dyspepsia, anorexia, increased appetite.
  • From the integumentary system: thinning of hair, rash (including erythematous and maculopapular).
  • From the reproductive system: vaginal bleedings, leukorrhea, bloody discharges from the vagina.
  • From the musculoskeletal system: muscular-skeletal pains (including pains in hands, back, legs, and skeleton).
  • From the vascular system: peripheral hypostases, thrombophlebitis.
  • Other: inflow, dyspnea, and raised hydrolysis.

Contra-indications

  • From the reproductive system: raised sensitivity to the active substance or any other component of the preparation, endocrine status characteristic of the premenopausal period.
  • Other: potential implications for hormonal balance and sensitivity during the premenopausal phase.

Safety measures

There is no data about the application of Femara for the patients with a clearance of creatinine <10 ml/mines. Before the prescription of Femara to such patients, the parity between potential risk and expected effect of treatment should be considered.

Pregnancy and lactation

The preparation Femara is counter-indicative during the periods of pregnancy and lactation.
Influences on the ability to drive the car and to operate mechanisms:
It is improbable, that application of Femara will break the ability of patients to drive the car or to operate mechanisms.

However, as at treatment by a preparation were observed the general weakness and dizzinesses, it is necessary to warn patients that their physical and-or mental abilities, which are required for driving of the car or management of mechanisms, maybe broken.

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