Gestanin – Allyloestrenol 5/25mg

Gestanin is a gestagen preparation, which stimulates the secretory phase in the myometrium, creates conditions for the development of the fertilized ovum. It has a tocolytic effect; reduces the sensitivity of the myometrium to oxytocin. It stimulates the development of acinus of mammary glands, the secretory activity of trophoblasts, development of aldosterone by adrenal glands.

It raises the deducing of metabolites of placentary steroids and secretion of androgenic gestagen, increases stocks of fat and recycling of glucose, promotes the accumulation of glycogen by a liver, normalizes the functioning of a placenta.

The preparation has an expressed protestation effect (similar to the effect of gestagens – hormones of a yellow body of the ovary) and plays a hormone-replacing role at pregnancy.

Gestagens are the female sexual hormones developed by a yellow body of ovary and by the cortex of adrenal glands, cause changes in the endometrium (an internal layer of a uterus), preparing it to implantation (introduction) of impregnated ovum, provide a normal course of pregnancy, reduce contractility of a uterus, especially pregnant, stimulate the development of milk-forming departments of mammary glands.

The preparation improves the secretory activity of trophoblasts (an external layer of cells at an embryo) and reduces the development of oxytocin as, increases the discharge of metabolites (products of exchange) of placentary steroids, that normalizes the functioning of a placenta, and also stimulates the secretion of androgenic progesterone (formation in an organism of a hormone of a yellow body of ovary), promoting the preservation of pregnancy.

Indications to application

Habitual and menacing abortion, the threat of premature birth.

Contra-indications

• From hypersensitivity: Allergic reactions (e.g., rash, itching, urticaria).
• From the hepatic system: Hepatic insufficiency, jaundice, elevated liver enzymes, potential for worsening of pre-existing liver conditions.
• From the endocrine system: Tumors of the mammary and sexual glands, potential hormonal imbalances.
• From the circulatory system: Thrombophlebitis, thromboembolic complications (e.g., deep vein thrombosis, pulmonary embolism), potential issues with blood circulation, particularly in the brain (increased risk of stroke).
• From the nervous system: Infringement of blood circulation in the brain (e.g., transient ischemic attacks, stroke).
• From the reproductive system: Gestosis (during or after pregnancy, particularly in those with a history of this condition).
• From infectious conditions: Herpes (may include recurrence or activation of latent infection, particularly if in the anamnesis).
• From lactation: Period of lactation (potential contraindications or effects on breastfeeding).

Collateral actions

• From the digestive system: dyspepsia, nausea, cholestatic jaundice.
• From the nervous system: a headache, depression, insomnia, or drowsiness.
• From urination systems: the holding of a liquid, a dropsical syndrome.
• Other: thrombophlebitis, thromboembolism, an increase of weight of a body, galactorrhea, swelling of mammary glands, hyperthermia, a decrease of tolerance to glucose.Also, acne rash, increase in weight of a body, cholestatic jaundice, hyperthermia can be marked.